MyBioSource.com's API-5 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Western Blot. The API-5 Antibody was generated using API5 as the antigen and it reacts with Human, and Mouse.
Description
Function: Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.
Subunit Structure: Monomer. Interacts with FGF2 and ACIN1.
Post-translational Modifications: Acetylation at Lys-251 impairs antiapoptotic function.
Similarity: Two regions, an N-terminal (aa 96-107) and a C-terminal (aa 274-311) are required for binding FGF2. Belongs to the API5 family